ProTG4
A web server to approximate the sequence of a generic protein from an in silico library of translatable G-quadruplex (TG4)-mapped peptides
NOTE:
  • ProTG4, approximates the sequence of a generic protein from an in silico library of TG4-mapped peptides (7-20 aa).

  • ProTG4, may also provide a quantitative measure to identify and thence annotate the canonical form for a generic protein sequence.

    •   
    1. Length ~7-50 amino acids::Library of equivalent length random sequences = 10000

    2. Length > 50 amino acids::Library of equivalent length random sequences = 100000

  • The confidence-of-sequence-identity, is then the weighted average of identical amino acid encompassing fragments from a randomly generated library of equivalent lengths.

  • The mapped peptides have been shown to associate with short linear motifs (SLiMS) (p-value < 0.05) and may predispose the protein to misfolding-induced proteostasis.

  • Since, the speed of calculation depends on the length of the INPUT sequences,
    DO NOT PRESS THE SUBMIT BUTTON MORE THAN ONCE

  • For best results (10-20s), please choose fewer (~5- 10) sequences of proteins (>100 amino acids).

  • These may be downloaded (Save As) or viewed directly

Paste your sequence(s) here :
Examples
CITATION:
Kundu S. ProTG4: a web server to approximate the sequence of a generic protein from an in silico library of translatable G-quadruplex (TG4)-mapped peptides. bioinform Biol Insights (2021), 15:11779322211045878. doi: 10.1177/11779322211045878 PMID: 34602814

                    
Contact information:
Siddhartha Kundu, MD, PhD
Associate Professor,
Department of Biochemistry,
All India Institute of Medical Sciences,
Ansari Nagar, New Delhi - 110029, INDIA

Email:
sidddhartha_kundu@yahoo.co.in siddhartha_kundu@aiims.edu
Schema to delineate peptides that correspond to TG4
Algorithm/pipeline of back-end analysis [1]
Codon table to identify suitable amino acids for peptide model of TG4 (~PTG4) [1]
CITATION:
[1] Kundu S. Mathematical model of a short translatable G-quadruplex and an assessment of its relevance to misfolding-induced proteostasis. Math Biosc Eng.(2020), 17(3):2470-2493. doi: 10.3934/mbe.2020135 PMID: 32233549